Opportunity Information: Apply for RFA FD 22 006
The Conformance with the Egg Regulatory Program Standards (U2F) cooperative agreement is a federal funding opportunity from the U.S. Department of Health and Human Services, Food and Drug Administration (FDA), aimed at strengthening a nationally integrated system for regulating shell eggs. The central purpose is to help state egg regulatory programs achieve and sustain full conformance with the Egg Regulatory Program Standards (ERPS), which are intended to bring more consistency, reliability, and effectiveness to how shell egg safety is overseen across the country. The opportunity is explicitly not for clinical trials, and it is positioned as a public health and consumer protection effort tied to agriculture and food safety.
The core outcome FDA is seeking is a measurable increase in state program alignment with the ERPS, so that egg regulatory work is carried out using comparable approaches and quality systems from state to state. In practice, that means supporting states as they build, document, and improve the foundational pieces of an effective regulatory program, such as inspection and compliance activities, enforcement decision-making, laboratory support, staff training, program assessment, and continuous improvement. The announcement frames the work as both an advancement toward conformance and a maintenance mechanism for programs that are already close to or at full conformance, recognizing that keeping a program in conformance requires ongoing capacity and oversight.
A major emphasis is on strengthening day-to-day egg regulatory and public health capabilities within the grantee state. This includes improving how the program plans and executes inspections, how it identifies and prioritizes risks, and how it responds when problems are found. The funding is meant to increase the effectiveness of regulatory activities that prevent or reduce egg-related illness, particularly illnesses linked to hazards associated with shell eggs. The scope is broad enough to cover facilities that produce, process, pack, hold, or transport shell eggs, and it also calls out materials and supplies connected to shell egg operations. Importantly, it highlights that the work should also address facilities that may not be subject to the federal Egg Rule, reflecting FDA's interest in reducing public health risk beyond only those operations directly covered under a single federal regulation.
Another key goal is better information-sharing and coordination. The opportunity specifically calls for sharing egg regulatory inspection information, compliance and enforcement information, and laboratory data between states and FDA. This focus reflects a systems approach where states are not working in isolation, and where data can be used more effectively for surveillance, trend analysis, and targeted interventions. By improving how information moves across jurisdictions and to the federal level, FDA is aiming for faster detection of emerging issues, more consistent oversight expectations, and better collective understanding of where the highest risks are in the shell egg supply chain.
The funding instrument is a cooperative agreement, which typically signals substantial federal involvement beyond what is common in a standard grant. In a cooperative agreement context, the recipient still leads the work, but FDA generally collaborates more actively through technical assistance, alignment with national program goals, and ongoing coordination. This structure fits the stated aim of building an integrated national system, because it supports ongoing interaction between state programs and FDA rather than one-off, standalone projects.
Administratively, the opportunity is identified as RFA FD 22 006 under CFDA 93.103, within the activity category of Agriculture, Consumer Protection, Food and Nutrition. It was posted on December 1, 2021, with an original closing date of January 31, 2022. The announcement projected up to 10 awards, with an award ceiling of $2,000,000, indicating a relatively significant investment per state program for building or sustaining the infrastructure needed to meet the ERPS. Eligibility is listed as "Others" with additional clarification referenced in the full announcement, which in context typically points toward state-level regulatory entities or comparable governmental programs responsible for egg oversight, rather than private companies or academic groups acting alone.
Overall, the opportunity is best understood as capacity-building for state regulatory systems with a clear national integration purpose: bringing state egg regulatory programs into full alignment with ERPS, improving public health protection through stronger inspection and enforcement functions, establishing more robust laboratory and data capabilities, and ensuring that states and FDA can share actionable regulatory information in a way that helps prevent shell egg-related illness across the entire supply chain.Apply for RFA FD 22 006
- The Department of Health and Human Services, Food and Drug Administration in the agriculture, consumer protection, food and nutrition sector is offering a public funding opportunity titled "Conformance with the Egg Regulatory Program Standards (U2F) (Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.103.
- This funding opportunity was created on Dec 01, 2021.
- Applicants must submit their applications by Jan 31, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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| Revision Applications - Development and Maintenance of the Animal Feed Regulatory Program Standards Flexible Funding Model Compliance and Enforcement Expansion Supplement (U18) (Clinical Trials Not Allowed) Apply for RFA FD 22 010 Funding Number: RFA FD 22 010 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $100,000 |
| Federal and State Integration Activities to Advance Cooperation and Regulatory Standards Among Animal Food Safety Regulatory Programs (U2F) Clinical Trials Not Allowed Apply for RFA FD 22 009 Funding Number: RFA FD 22 009 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $350,000 |
| Revision Applications - Manufactured Food Flexible Funding Model Compliance and Enforcement Expansion Supplement (U18) (Clinical Trials Not Allowed) Apply for RFA FD 22 019 Funding Number: RFA FD 22 019 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $100,000 |
| Retail Food Safety Regulatory Association Collaboration (U18) (Clinical Trial Not Allowed) Apply for RFA FD 22 008 Funding Number: RFA FD 22 008 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Renewal - Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 22 025 Funding Number: RFA FD 22 025 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| Renewal- Local Food Producer Outreach, Education, and Training to Enhance Food Safety and FDA Food Safety Modernization Act (FSMA) Compliance (U01) Clinical Trail Not Allowed Apply for RFA FD 22 024 Funding Number: RFA FD 22 024 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Funding Opportunity Title Innovation Award: Minority Health and Health Equity (U01) Clinical Trials Optional Apply for RFA FD 22 005 Funding Number: RFA FD 22 005 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| OMHHE Educational Funding Opportunity: Expanding education on skin lightening products (U01) Clinical Trials Optional Apply for RFA FD 22 020 Funding Number: RFA FD 22 020 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $250,000 |
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| Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed Apply for RFA FD 23 027 Funding Number: RFA FD 23 027 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $565,000 |
| Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Clinical Trials Not Allowed Apply for RFA FD 23 019 Funding Number: RFA FD 23 019 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $360,000 |
| Renewal-Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 23 032 Funding Number: RFA FD 23 032 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| Renewal-Local Food Producer Outreach, Education and Training to Enhance Food Safety and FDA Food Safety Modernization Act (FSMA) Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 23 031 Funding Number: RFA FD 23 031 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Vet-LIRN Capacity-Building Project and Equipment Grants (U18) Apply for PAR 23 202 Funding Number: PAR 23 202 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,500,000 |
| Cooperative Agreement to Support an Evidence-Based Clinical Practice Guideline for the Management of Laparoscopic Abdominal Surgeries (U01) Clinical Trials Not Allowed Apply for RFA FD 23 035 Funding Number: RFA FD 23 035 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,000,000 |
| Cooperative Agreement to Support an Evidence-Based Clinical Practice Guideline for the Management of Acute Low Back Pain (U01) Clinical Trials Not Allowed Apply for RFA FD 23 034 Funding Number: RFA FD 23 034 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,000,000 |
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