Opportunity Information: Apply for RFA CA 21 016
Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) is a National Cancer Institute (NCI) funding opportunity that supports the ongoing operation, maintenance, and improvement of existing informatics tools and resources that are already widely used in the cancer research community. Rather than funding brand-new software or early prototypes, this program is aimed at keeping high-value, proven resources running reliably, making them easier to use, and ensuring they remain available and responsive to the needs of researchers over time. The overall goal is to strengthen how data and knowledge are collected, managed, analyzed, and shared across the full cancer research continuum, including basic cancer biology, diagnosis and treatment, early detection, risk assessment and prevention, cancer control and epidemiology, and cancer health disparities research.
The award mechanism is a Cooperative Agreement (U24), meaning recipients should expect substantial involvement from NCI program staff compared to a standard research grant. In practical terms, this typically reflects an expectation of active coordination, shared planning, and ongoing alignment with ITCR program priorities. The opportunity sits within NCI's Informatics Technology for Cancer Research (ITCR) Program, whose mission is to promote research-driven informatics technology across the full development lifecycle. This particular FOA emphasizes the sustainment phase of that lifecycle: keeping mature, broadly adopted resources healthy, secure, and useful, while also improving user experience, usability, and access. Companion ITCR FOAs cover the earlier phases where tools are created and advanced; this one is for resources that have already demonstrated real-world uptake and impact.
Applications are expected to present a clear sustainment plan and a strong justification for why the resource should continue to be supported. That justification should go beyond general statements and instead show concrete evidence of benefit to the cancer research field, such as demonstrated usage, integration into workflows, impact on research productivity or reproducibility, and the resource's role in enabling data sharing or analysis at scale. A competitive proposal would also describe how the team will continue to evolve operations without drifting into unfocused redevelopment, balancing stability with thoughtful improvements that remove friction for users and address real, documented needs.
A key expectation is deep engagement with the intended user community. Applicants should describe specific mechanisms for assessing and maximizing the value of the resource to researchers, such as user feedback programs, governance structures, advisory boards, community forums, documentation and training, help desk support, and clear processes for prioritizing enhancements. The FOA also highlights collaboration, implying that successful projects will not operate in isolation, but will work closely with the research communities they serve and, where appropriate, align with related NCI and NIH data standards, platforms, and interoperability efforts.
Eligibility is broad and includes various levels of government entities, public and private institutions of higher education, tribal governments and organizations, nonprofit organizations (including both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and other entities as described in the full announcement. The sponsoring agency is the U.S. Department of Health and Human Services, National Institutes of Health. The opportunity number is RFA-CA-21-016, with CFDA listings spanning multiple NCI-related numbers (93.393, 93.394, 93.395, 93.396, 93.399). The FOA anticipated making a small number of awards (expected awards: 2). The award ceiling is listed as 0, which typically indicates that a specific cap is not stated in that field and applicants must rely on FOA guidance and budget justification expectations. The original posting date was December 2, 2020, with an original closing date of November 17, 2021.
Overall, the opportunity is best understood as NCI support for keeping critical cancer informatics infrastructure dependable and continually useful: strengthening availability, improving the user experience, demonstrating ongoing community benefit, and building structured, measurable ways to ensure the tool or resource remains valuable to cancer researchers and the broader cancer data ecosystem.Apply for RFA CA 21 016
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Dec 02, 2020.
- Applicants must submit their applications by Nov 17, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Applicants who have applied for this opportunity (RFA CA 21 016) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 21 018 Funding Number: RFA CA 21 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 21 013 Funding Number: RFA CA 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 21 017 Funding Number: RFA CA 21 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional) Apply for RFA CA 21 019 Funding Number: RFA CA 21 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 21 092 Funding Number: PAR 21 092 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) Apply for RFA DA 21 029 Funding Number: RFA DA 21 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $575,000 |
| Limited Competition to Convert the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Study Cohort to a Research Resource (R24 - Clinical Trial Not Allowed) Apply for RFA MH 21 170 Funding Number: RFA MH 21 170 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Proteogenomic Data Analysis Centers (PGDACs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 024 Funding Number: RFA CA 21 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Proteogenomic Translational Research Centers (PTRCs) for Clinical Proteomic Tumor Analysis Consortium (U01 Clinical Trial Not Allowed) Apply for RFA CA 21 025 Funding Number: RFA CA 21 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 023 Funding Number: RFA CA 21 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 21 037 Funding Number: RFA CA 21 037 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Coordinating Center for Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) in Cancer Survivors Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 032 Funding Number: RFA CA 21 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $875,000 |
| Network of the National Library of Medicine All of Us Program Center (U24) (Clinical Trial Optional) Apply for RFA LM 21 002 Funding Number: RFA LM 21 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,200,000 |
| Cancer Target Discovery and Development (CTD2) (U01 Clinical Trial Not Allowed) Apply for PAR 21 274 Funding Number: PAR 21 274 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Indian Health Service National Indian Health Outreach and Education Apply for HHS 2023 IHS NIHOE 0001 Funding Number: HHS 2023 IHS NIHOE 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Education, Health Funding Amount: $851,311 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 032 Funding Number: RFA CA 22 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Apply for RFA CA 22 046 Funding Number: RFA CA 22 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Translational Research Centers (U01 Clinical Trial Optional) Apply for RFA CA 22 031 Funding Number: RFA CA 22 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| American Indians into Medicine Apply for HHS 2024 IHS INMED 0001 Funding Number: HHS 2024 IHS INMED 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $700,000 |
| American Indians into Nursing Apply for HHS 2024 IHS NU 0001 Funding Number: HHS 2024 IHS NU 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $400,000 |
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